A package containing ricin poison that was addressed to US President Donald Trump has been intercepted before it reached the White House, officials told US media.
The letter was discovered at a screening facility for White House mail earlier this week, the officials said.
They said a substance found inside the envelope was identified as ricin, a poison found naturally in castor beans.
The Trump administration is yet to comment on the reports.
The Federal Bureau of Investigation (FBI) and the Secret Service are investigating where the package came from and whether others have been sent through the US postal system.
“At this time, there is no known threat to public safety,” the FBI told CNN in a statement on Saturday.
One official told the New York Times that investigators believe the package was sent from Canada. Reports say the presence of ricin was confirmed after tests by the FBI.
The Royal Canadian Mounted Police (RCMP) said on Saturday it was working with the FBI to investigate the “suspicious letter sent to the White House”.
Ricin is produced by processing castor beans. It is a lethal substance that, if swallowed, inhaled or injected, can cause nausea, vomiting, internal bleeding and ultimately organ failure.
No known antidote exists for ricin. If a person is exposed to ricin, death can take place within 36 to 72 hours, depending on the dose received, according to the US Centers for Disease Control and Prevention (CDC).
The CDC said the poison – which has been used in terror plots – can be manufactured into a weapon in the form of a powder, mist or pellet.
The White House and other federal buildings have been the target of ricin packages in the past.
In 2014, a Mississippi man was sentenced to 25 years in prison for sending letters dusted with ricin to former President Barack Obama and other officials.
Four years later, in 2018, a former Navy veteran was charged with sending toxic letters to the Pentagon and White House.